This advertising print from 1849 shows the five-story storefront, adorned with signage and an ornamental ironwork balcony, of the druggist located at 100 North Third Street, Philadelphia. A patron enters the establishment as a crate is hoisted in front of him. To the left, the window and second entrance of the building are open, and casks, jugs, bottles, and boxes line a wall of shelves and the floor. Additional inventory is visible near the upper windows. A clerk oversees the loading of a cart with boxes and barrels, while pedestrians pass by on the sidewalk. John Baker’s business tenanted the site from 1849. The firm was one of the founding members of the Philadelphia Drug Exchange in 1861.The print is by William H. Rease, the most prolific lithographer of advertising prints in Philadelphia during the 1840s and 1850s. Born in Pennsylvania circa 1818, Rease became active in his trade around 1844. Through the 1850s he mainly worked with printers Frederick Kuhl and Wagner & McGuigan in the production of advertising prints known for their portrayals of human details. Although Rease often collaborated with other lithographers, a listing in O'Brien's Business Directory indicates that by 1850 he had founded his own establishment at 17 South Fifth Street, north of Chestnut Street. After a partnership with Francis Schell that lasted from about 1853 to 1855, in 1855 he relocated his shop to the northeast corner of Fourth and Chestnut Streets, where, in addition to advertising prints, he produced certificates, views, maps, and maritime prints.