This manuscript is the only known work in the hand of Artemiĭ Vedelʹ (1767–1808), one of the most famous Ukrainian composers. It consists of six parts of the Liturgy of Saint John Chrysostom, 12 spiritual choral pieces, and a composition for trio with choir. Different colors of ink reflect the fact that the compositions were written at different times over a period of several years. In 1856 the historian, publicist, and professor at the Kiev Theological Academy, V.I. Askochenskyi, offered the score as a gift to the library of the academy, and in 1872 it went to the church archaeological museum of the academy. The compositions in the manuscript are all masterpieces of late-18th century Ukrainian music. This authentic autograph score has great scientific value, as it makes possible comparative manuscript research on copies of other works by Vedelʹ, with the aim of possibly identifying more autograph scores. This work is in the collection of the V.I. Vernadsky National Library of Ukraine.